Type 2 diabetes mellitus

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Very commonModerately severe

Disease characterised by high levels of glucose in the blood. The resistance of the cells to insulin and/or the lack of insulin means that the glucose circulating in the blood cannot be taken up and used by the body's cells. Type 2 diabetes accounts for 90% of all diabetes.

It becomes more common with age and is associated with factors such as obesity, high blood pressure, elevated cholesterol, a sedentary lifestyle and a family history of diabetes.

In the early stages, there are no symptoms until the lack of glucose in the cells and its accumulation in the blood causes hunger and thirst, with increased fluid intake and, consequently, an increase in urine. Other associated symptoms include fatigue, weight loss, nausea and vomiting, irritability and blurred vision.

The diagnosis is usually an analytical finding until the onset of symptoms. It is confirmed by a blood glucose level of more than 200 mg/dl, or more than 126 mg/dl in the fasting state.

Treatment is based on lifestyle changes such as weight loss, dietary control and regular exercise. If high blood glucose levels persist, treatment with oral antidiabetic drugs ± insulin is started.

Bibliographic references
  • Standl, E.; Khunti, K.; Hansen, T.B.; Schnell, O. The global epidemics of diabetes in the 21st century: Current situation and perspectives. Eur. J. Prev. Cardiol. 2019, 26, 7–14.
  • Dall, T.M.; Narayan, K.M.; Gillespie, K.B.; Gallo, P.D.; Blanchard, T.D.; Solcan, M.; O’Grady, M.; Quick, W.W. Detecting type 2 diabetes and prediabetes among asymptomatic adults in the United States: Modeling American Diabetes Association versus US Preventive Services Task Force diabetes screening guidelines. Popul. Health Metr. 2014, 12, 12.
  • Stevens, J.W.; Khunti, K.; Harvey, R.; Johnson, M.; Preston, L.; Woods, H.B.; Davies, M.; Goyder, E. Preventing the progression to type 2 diabetes mellitus in adults at high risk: A systematic review and network meta-analysis of lifestyle, pharmacological and surgical interventions. Diabetes Res. Clin. Pract. 2015, 107, 320–331.
  • Vistisen, D.; Witte, D.R.; Brunner, E.J.; Kivimaki, M.; Tabak, A.; Jorgensen, M.E.; Faerch, K. Risk of Cardiovascular Disease and Death in Individuals With Prediabetes Defined by Different Criteria: The Whitehall II Study. Diabetes Care 2018, 41, 899–906.
  • Saeedi, P.; Petersohn, I.; Salpea, P.; Malanda, B.; Karuranga, S.; Unwin, N.; Colagiuri, S.; Guariguata, L.; Motala, A.A.; Ogurtsova, K.; et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9(th) edition. Diabetes Res. Clin. Pract. 2019, 157, 107843.
  • NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4·4 million participants. Lancet 2016, 387, 1513–1530.
  • Barry, E.; Roberts, S.; Oke, J.; Vijayaraghavan, S.; Normansell, R.; Greenhalgh, T. Efficacy and effectiveness of screen and treat policies in prevention of type 2 diabetes: Systematic review and meta-analysis of screening tests and interventions. BMJ 2017, 356, i6538.
  • Jose Angel Ayensa-Vazquez, Alfonso Leiva, Pedro Tauler, Angel Arturo López-González, Antoni Aguiló, Matías Tomás-Salvá, Miquel Bennasar-Veny. «Agreement between Type 2 Diabetes Risk Scales in a Caucasian Population: A Systematic Review and Report». J. Clin. Med. 2020, 9(5), 1546.
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Symptoms

    Blood glucose levels over 200 mg/dL


    Frequent urination


    Urinate a lot at night


    Overweight or obese, BMI between 25 and 29.9


    Thirst

Symptoms to watch out for

Thirst increase
Dark or cola-coloured urine
If it is accompanied by seizures
A feeling of shortness of breath
Vomiting
Acute belly pain
Blurry vision

Self-care

Maintain a balanced diet: increase fruit, vegetable, and white meat consumption and reduce the intake of fatty meals and fritters.
Engage in regular physical activity, adapted to age and physical condition, at least 3 times a week.
Reduce tobacco consumption.
Wear comfortable, non-constricting footwear.
Lose weight if you are overweight or obese.
Check with your general practitioner about the prescription for medication to control blood glucose and insulin levels.
Check your symptoms and get a pre-diagnosis